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2 Selectin L-selectin P-selectin E-selectin Selectins, cells and structures that express them, their functions, and ligands Ligands PSGL-1, GlyCAM-1, MAdCAM-1, CD34 PSGL-1 PSGL-1 Expression Leukocytes Platelets, endothelium Endothelium Functions Leukocyte trafficking, rolling adhesion Rolling adhesion Rolling adhesion induced by inflammation PSGL-1, P-selectin glycoprotein ligand-1; MAdCAM-1, mucosal-addressing cellular adhe- sion molecule-1; GlyCAM-1, glycosylation-dependent cell adhesion molecule-1.
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